Copper (I)-Chloroquine Complexes: Interactions with DNA and Ferriprotoporphyrin, Inhibition of β-Hematin Formation and Relation to Antimalarial Activity.

ABSTRACT: A new Cu(I)-chloroquine (CQ) complex [Cu(CQ)(PPh₃)₂]NO₃ (1) was synthesized and characterized, and its mechanism of action studied concomitant with the previously reported complex [Cu(CQ)₂]Cl (2). These copper (I) coordination compounds can be considered as potential antimalarial agents because they show better inhibition of the CQ-resistant strain in in vitro studies than CQ alone. In comparison with other metal-CQ complexes, only the gold complex was similar to (1), i.e., more active than CQ against both CQ-susceptible (3D7) and CQ-resistant strains (W2). These two copper (I)-compounds also demonstrated higher antiplasmodial activity against W2 than other copper complexes reported to date. This suggests that the incorporati

SUBMITTER: Villarreal W 

PROVIDER: S-EPMC9329717 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature