Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation.

ABSTRACT: In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-gene

SUBMITTER: Arleevskaya M 

PROVIDER: S-EPMC9329780 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature