Metabolomics Approach on Non-Targeted Screening of 50 PPCPs in Lettuce and Maize.

ABSTRACT: The metabolomics approach has proved to be promising in achieving non-targeted screening for those unknown and unexpected (U&U) contaminants in foods, but data analysis is often the bottleneck of the approach. In this study, a novel metabolomics analytical method via seeking marker compounds in 50 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked into lettuce and maize matrices was developed, based on ultrahigh-performance liquid chromatography-tandem mass spectrometer (UHPLC-MS/MS) output results. Three concentration groups (20, 50 and 100 ng mL^-1) to simulate the control and experimental groups applied in the traditional metabolomics analysis were designed to discover marker compounds, for which multivariate and univariate analysis were adopted. In m

SUBMITTER: Xue W 

PROVIDER: S-EPMC9330060 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature