Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.

ABSTRACT: It is well known that the properties of hematopoietic stem/progenitor cells (HSCs), such as their self-renewal ability and multipotency, are maintained through interactions with mesenchymal stem/stromal cells (MSCs). MSCs are rare cells that are present in the bone marrow and are useful for clinical applications due to their functional ability. To obtain the necessary number of cells, MSCs must be cultured to expand, but this causes a remarkable decrease in stem cell properties, such as multipotency and proliferation ability. In this study, we show that the c-Mpl signal, which is related to the maintenance of hematopoietic stem cells, has an important effect on the proliferation and differentiation ability of MSCs. Utilizing a co-culture system comprising MSCs and HSCs, it is suggested tha

SUBMITTER: Kanazawa S 

PROVIDER: S-EPMC9330127 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature