Oral Contraceptive and Glioma Risk: A Prospective Cohort Study and Meta-Analysis.

ABSTRACT:

Background

Epidemiological evidence that glioma has a slight male predominance implies that factors associated with sex hormones may play a role in the development of glioma. The association between oral contraceptive (OC) use and glioma risk remains controversial.

Method

In the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial of 70,516 women in the USA, Cox proportional hazards regression analyses were adopted to calculate the crude and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Additionally, a meta-analysis combining the PLCO findings with those of other prospective cohorts was performed.

Results

During a mean follow-up of ~11.7 years, 110 of 70,516 women aged 50-78 years at baseline were diagnosed with glioma in PLCO studi

SUBMITTER: Shao C 

PROVIDER: S-EPMC9330220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature