Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder Across Neuroimaging Modalities.

ABSTRACT:

Importance

Identifying neurobiological differences between patients with major depressive disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta-analyses have raised concerns regarding the replicability and clinical relevance of brain alterations in depression.

Objective

To quantify the upper bounds of univariate effect sizes, estimated predictive utility, and distributional dissimilarity of healthy individuals and those with depression across structural magnetic resonance imaging (MRI), diffusion-tensor imaging, and functional task-based as well as resting-state MRI, and to compare results with an MDD polygenic risk score (PRS) and environmental variables.

Design, setting, and participants

This was a cros

SUBMITTER: Winter NR 

PROVIDER: S-EPMC9330277 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature