Quantum Cascade Laser-Based Vibrational Circular Dichroism Augmented by a Balanced Detection Scheme.

ABSTRACT: Vibrational circular dichroism (VCD) constitutes a powerful technique, enabling the determination of the absolute configuration of molecules without the need for specialized reagents. While delivering critical information, VCD signals commonly are several orders of magnitude weaker than classical absorbance signals, which so far necessitated long measurement times to achieve acceptable signal-to-noise ratios (SNRs) in VCD experiments. We present here an improved setup for the measurement of VCD in the range between 5.6 and 6.5 μm. Employing an external cavity quantum cascade laser (EC-QCL) as a high-power light source, we collected spectra with competitive noise levels in less than 5 min. The basis for this improvement was a balanced detection module combined with an optical path catered t

SUBMITTER: Hermann DR 

PROVIDER: S-EPMC9330291 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature