XBP1 is required in Th2 polarization induction in airway allergy.

ABSTRACT: Rationale: Th2 polarization plays a central role in the pathogenesis of allergic diseases such as airway allergy. The underlying mechanism is not fully understood yet. X-box-binding protein-1 (XBP1) can regulate immune cell activities upon exposing stressful events. The role of XBP1 in the development of Th2 polarization has not yet been explored. Methods: Mice carrying Xbp1-deficient CD4⁺ T cells were employed to observe the role of XBP1 in the induction of airway allergy. A cell culture model was established to evaluate the role of XBP1 in facilitating the Th2 lineage commitment. Results: We found that Xbp1 ablation in CD4⁺ T cells prevented induction of Th2 polarization in the mouse airway tract. XBP1 was indispensable in the Th2

SUBMITTER: Zeng X 

PROVIDER: S-EPMC9330522 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature