Dedifferentiated Schwann cell-derived TGF-β3 is essential for the neural system to promote wound healing.

ABSTRACT: Rationale: Wound healing is among the most complicated physiological processes and requires the synchronization of various cell types with distinct roles to re-establish the condition of the original skin. Patients affected by peripheral neuropathies often experience failure to heal. Loss of Schwann cells (SCs), a crucial population of peripheral nervous system cells in skin, may contribute to chronic wounds. However, the role of SCs in wound healing are poorly understood. Methods: The activity of SCs was investigated by using a cell atlas of the wound healing process, which was generated by integrating single-cell RNA sequencing (scRNA-seq) libraries covering different states of mouse back skin. The results of in silico analysis were validated by in vitro cell culture

SUBMITTER: Ou MY 

PROVIDER: S-EPMC9330527 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature