Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome.

ABSTRACT:

Background and aims

Lynch syndrome is associated with pathogenic variants in 4 mismatch repair (MMR) genes that increase lifetime risk of colorectal cancer. Guidelines recommend intensive colorectal cancer surveillance with colonoscopy every 1-2 years starting at age 25 years for all carriers of Lynch syndrome-associated variants, regardless of gene product. We constructed a simulation model to analyze the effects of different ages of colonoscopy initiation and surveillance intervals for each MMR gene (MLH1, MSH2, MSH6, and PMS2) on colorectal cancer incidence and mortality, quality-adjusted life-years, and cost.

Methods

Using published literature, we developed a Markov simulation model of Lynch syndrome progression for patients with each MMR variant. The model simulated cli

SUBMITTER: Kastrinos F 

PROVIDER: S-EPMC9330543 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature