Prognostic biomarker IL17A correlated with immune infiltrates in head and neck cancer.

ABSTRACT:

Background

The underlying functions and mechanisms of the Th17 pathway in Head and neck squamous cell carcinoma (HNSCC) progression and tumor immunology are still unclear. We investigated the correlation between IL17A expression and certain clinical parameters, tumor-infiltrating immune cells (TIICs) in TCGA HNSCC samples.

Methods

HNSCC files from the TCGA database were analyzed to obtain data on immune system infiltrates, gene expression, and related clinical information. R (Version 3.6.3) software, GEPIA, and TIMER online analysis tools were used to profile the relationship between the expression of IL17A and the prognosis, clinical stages, survival status and immune cell tumor-infiltrating levels of HNSCC patients. GEPIA and TIMER online analysis tools were used to verify

SUBMITTER: Yu M 

PROVIDER: S-EPMC9330648 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature