Impact of direct-acting antiviral treatment of hepatitis C on the quality of life of adults in Ukraine.

ABSTRACT:

Background

Direct-acting antivirals (DAAs) are highly effective in achieving sustained virologic response among those with chronic hepatitis C virus (HCV) infection. Quality of life (QOL) benefits for an HCV-infected population with high numbers of people who inject drugs and people living with HIV (PLHIV) in Eastern Europe have not been explored. We estimated such benefits for Ukraine.

Methods

Using data from a demonstration study of 12-week DAA conducted in Kyiv, we compared self-reported QOL as captured with the MOS-SF20 at study entry and 12 weeks after treatment completion (week 24). We calculated domain scores for health perception, physical, role and social functioning, mental health and pain to at entry and week 24, stratified by HIV status.

Results

Among the

SUBMITTER: Benade M 

PROVIDER: S-EPMC9330669 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature