KLF9 and EPYC acting as feature genes for osteoarthritis and their association with immune infiltration.

ABSTRACT:

Background

Osteoarthritis, a common degenerative disease of articular cartilage, is characterized by degeneration of articular cartilage, changes in subchondral bone structure, and formation of osteophytes, with main clinical manifestations including increasingly serious swelling, pain, stiffness, deformity, and mobility deficits of the knee joints. With the advent of the big data era, the processing of mass data has evolved into a hot topic and gained a solid foundation from the steadily developed and improved machine learning algorithms. Aiming to provide a reference for the diagnosis and treatment of osteoarthritis, this paper using machine learning identifies the key feature genes of osteoarthritis and explores its relationship with immune infiltration, thereby revealing its pa

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9330685 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature