Nanoscale Features of Tunable Bacterial Outer Membrane Models Revealed by Correlative Microscopy.

ABSTRACT: The rise of antibiotic resistance is a growing worldwide human health issue, with major socioeconomic implications. An understanding of the interactions occurring at the bacterial membrane is crucial for the generation of new antibiotics. Supported lipid bilayers (SLBs) made from reconstituted lipid vesicles have been used to mimic these membranes, but their utility has been restricted by the simplistic nature of these systems. A breakthrough in the field has come with the use of outer membrane vesicles derived from Gram-negative bacteria to form SLBs, thus providing a more physiologically relevant system. These complex bilayer systems hold promise but have not yet been fully characterized in terms of their composition, ratio of natural to synthetic components, and membrane protein content

SUBMITTER: Bali K 

PROVIDER: S-EPMC9330759 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature