Evolution of the Membrane Transport Protein Domain.

ABSTRACT: Membrane transport proteins are widely present in all living organisms, however, their function, transported substrate, and mechanism of action are unknown. Here we use diverse bioinformatics tools to investigate the evolution of MTPs, analyse domain organisation and loop topology, and study the comparative alignment of modelled 3D structures. Our results suggest a high level of conservancy between MTPs from different taxa on both amino acids and structural levels, which imply some degree of functional similarities. The presence of loop/s of different lengths in various positions suggests tax-on-specific adaptation to transported substrates, intracellular localisation, accessibility for post-translation modifications, and interaction with other proteins. The comparison of modelled structur

SUBMITTER: Dabravolski SA 

PROVIDER: S-EPMC9330825 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature