Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation.

ABSTRACT: The development of antibiotic resistance as an unavoidable consequence of the application of antimicrobials is a significant concern for human health. Antidepressants are being increasingly consumed globally. Human gut microbial communities are frequently exposed to antidepressants, yet little is known about the interaction between antidepressants and antibiotic resistance. This study aimed to investigate whether antidepressants can accelerate the dissemination of antibiotic resistance by increasing the rate of the horizontal transfer of antibiotic resistance genes (ARGs). Results demonstrated that some of the commonly-prescribed antidepressants (Duloxetine, Sertraline, Fluoxetine and Bupropion) at clinically relevant concentrations can significantly (n = 9; p_adj < 0.01) promote

SUBMITTER: Lu J 

PROVIDER: S-EPMC9330934 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature