Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders.

ABSTRACT:

Background

Herbicides are environmental contaminants that have gained much attention due to the potential hazards they pose to human health. Glyphosate, the active ingredient in many commercial herbicides, is the most heavily applied herbicide worldwide. The recent rise in glyphosate application to corn and soy crops correlates positively with increased death rates due to Alzheimer's disease and other neurodegenerative disorders. Glyphosate has been shown to cross the blood-brain barrier in in vitro models, but has yet to be verified in vivo. Additionally, reports have shown that glyphosate exposure increases pro-inflammatory cytokines in blood plasma, particularly TNFα.

Methods

Here, we examined whether glyphosate infiltrates the brain and elevates TNFα levels in 4-month-ol

SUBMITTER: Winstone JK 

PROVIDER: S-EPMC9331154 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature