The value of urinary gonadotropins in the diagnosis of central precocious puberty: a meta-analysis.

ABSTRACT:

Background

The gonadotropin-releasing hormone (GnRH) stimulation test is time-consuming, invasive, and costly. However, it is the diagnostic gold standard for central precocious puberty (CPP), which in girls is defined as the onset of secondary sexual characteristics before the age of 8 years accompanied by breast buds, accelerated growth, and advanced bone age. This meta-analysis was performed to compare the diagnostic value of urinary gonadotropins and the GnRH stimulation test for CPP.

Methods

We searched six databases for relevant literature. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we estimated the sensitivity, specificity, area under the summary receiver operating characteristic curve (AUC), and publication b

SUBMITTER: Xu D 

PROVIDER: S-EPMC9331156 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature