High-frequency neuromodulation improves obsessive-compulsive behavior.

ABSTRACT: Nearly one billion people worldwide suffer from obsessive-compulsive behaviors^1,2, yet our mechanistic understanding of these behaviors is incomplete, and effective therapeutics are unavailable. An emerging perspective characterizes obsessive-compulsive behaviors as maladaptive habit learning^3,4, which may be associated with abnormal beta-gamma neurophysiology of the orbitofrontal-striatal circuitry during reward processing^5,6. We target the orbitofrontal cortex with alternating current, personalized to the intrinsic beta-gamma frequency of the reward network, and show rapid, reversible, frequency-specific modulation of reward- but not punishment-guided choice behavior and learning, driven by increased exploration in the setting of an actor-critic architect

SUBMITTER: Grover S 

PROVIDER: S-EPMC9331184 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature