Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations.

ABSTRACT: Understanding mechanisms that underly the transition from acute to chronic pain and identifying potential targets for preventing or minimizing this progression have specific relevance for chronic postsurgical pain (CPSP). Though it is clear that multiple psychosocial, family, and environmental factors may influence CPSP, this review will focus on parallels between clinical observations and translational laboratory studies investigating the acute and long-term effects of surgical injury on nociceptive pathways. This includes data related to alterations in sensitivity at different points along nociceptive pathways from the periphery to the brain; age- and sex-dependent mechanisms underlying the transition from acute to persistent pain; potential targets for preventive interventions; and the

SUBMITTER: Walker SM 

PROVIDER: S-EPMC9331197 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature