Low abundance members of the gut microbiome exhibit high immunogenicity.

ABSTRACT: Studies identifying bacterial members that dictate host phenotype have focused mainly on the dominant members, and the role of low abundance microbes in determining host phenotypes and pathogenesis of diseases remains unexplored. In this study, we compared the gut bacterial community of mice with wide-ranging microbial exposure to determine if low abundance bacteria vary based on microbial exposure or remain consistent. We noted that similar to the high abundance bacterial community, a core community of low abundance bacteria made up a significant portion of the gut microbiome irrespective of microbial exposure. To determine the role of low abundance bacteria in regulating community composition and host gene expression, we devised a microbiome dilution strategy to "delete" out low abundanc

SUBMITTER: Han G 

PROVIDER: S-EPMC9331198 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature