Developing ROR1 Targeting CAR-T Cells against Solid Tumors in Preclinical Studies.

ABSTRACT: Chimeric antigen receptor (CAR)-modified T-cells (CAR-T) have demonstrated promising clinical benefits against B-cell malignancies. Yet, its application for solid tumors is still facing challenges. Unlike haematological cancers, solid tumors often lack good targets, which are ideally expressed on the tumor cells, but not by the normal healthy cells. Fortunately, receptor tyrosine kinase-like orphan receptor 1 (ROR1) is among a few good cancer targets that is aberrantly expressed on various tumors but has a low expression on normal tissue, suggesting it as a good candidate for CAR-T therapy. Here, we constructed two ROR1 CARs with the same antigen recognition domain that was derived from Zilovertamab but differing in hinge regions. Both CARs target ROR1⁺ cancer cells specifically

SUBMITTER: Lee BK 

PROVIDER: S-EPMC9331269 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature