The Extent of Lifestyle-Induced Weight Loss Determines the Risk of Prediabetes and Metabolic Syndrome Recurrence during a 5-Year Follow-Up.

ABSTRACT: It is controversial whether lifestyle-induced weight loss (LIWL) intervention provides long-term benefit. Here, we investigated whether the degree of weight loss (WL) in a controlled LIWL intervention study determined the risk of prediabetes and recurrence of metabolic syndrome (MetS) during a 5-year follow-up. Following LIWL, 58 male participants (age 45-55 years) were divided into four quartiles based on initial WL: Q1 (WL 0-8.1%, n = 15), Q2 (WL 8.1-12.8%, n = 14), Q3 (WL 12.8-16.0%, n = 14), and Q4 (WL 16.0-27.5%, n = 15). We analyzed changes in BMI, HDL cholesterol, triglycerides (TGs), blood pressure, and fasting plasma glucose (FPG) at annual follow-up visits. With a weight gain after LIWL between 1.2 (Q2) and 2.5 kg/year (Q4), the reduction in BMI was ma

SUBMITTER: Zimmermann S 

PROVIDER: S-EPMC9331424 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature