ABCB9 polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population.

ABSTRACT:

Background

Schizophrenia (SCZ) is a complex disease which can be affected by both genetic and environmental factors. Prenatal famine exposure may cause changes in DNA methylation levels of genes. Meanwhile, maternal nutrition during pregnancy is a pivotal environmental factor in the development of SCZ. DNA methylation may be an intermediate factor mediating exposure to famine during pregnancy and SCZ, and DNA methylation quantitative trait loci might serve as a promising tool for linking SCZ and prenatal famine.

Aim

To analyze the association between prenatal famine exposure and SCZ risk in Northeast Han Chinese through analysis of DNA methylation related loci.

Methods

A total of 954 Han Chinese from Northeast China were recruited, including 443 patients with SCZ and

SUBMITTER: Li XW 

PROVIDER: S-EPMC9331447 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature