Inulin reduces visceral adipose tissue mass and improves glucose tolerance through altering gut metabolites.

ABSTRACT:

Aim

Inulin, a soluble dietary fiber, is a source of energy for the host while the metabolites, such as short-chain fatty acids (SCFAs), produced in the gut through bacterial fermentation exerts the anti-obesity effect. In this study, we aimed to apply a metabolomics approach and clarify the role of this soluble dietary fiber on glucose and lipid metabolism under the calorie-matched condition.

Materials and methods

Eight-week-old male C57BL/6J mice were fed a high-fat/high-sucrose based diet containing maltodextrin or inulin for 12 weeks through calorie-matched pair feeding. We evaluated glucose tolerance, and energy expenditure using indirect calorimetry, comprehensive metabolites in the content of jejunum, feces, and portal vein serum using gas chromatography-mass spectrome

SUBMITTER: Nakajima H 

PROVIDER: S-EPMC9331483 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature