Combined Cytotoxic Effect of Inhibitors of Proteostasis on Human Colon Cancer Cells.

ABSTRACT: Despite significant progress in the diagnosis and treatment of colorectal cancer, drug resistance continues to be a major limitation of therapy. In this regard, studies aimed at creating combination therapy are gaining popularity. One of the most promising adjuvants are inhibitors of the proteostasis system, chaperone machinery, and autophagy. The main HSP regulator, HSF1, is overactivated in cancer cells and autophagy sustains the survival of malignant cells. In this work, we focused on the selection of combination therapy for the treatment of rectal cancer cells obtained from patients after tumor biopsy without prior treatment. We characterized the migration, proliferation, and chaperone status in the resulting lines and also found them to be resistant to a number of drugs widely used in

SUBMITTER: Nikotina AD 

PROVIDER: S-EPMC9331496 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature