Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal.

ABSTRACT: Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%-15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%-12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antir

SUBMITTER: Ramirez Mena A 

PROVIDER: S-EPMC9331503 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature