Ontology highlight
ABSTRACT:
SUBMITTER: Conter C
PROVIDER: S-EPMC9331509 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Conter Carolina C Fruncillo Silvia S Favretto Filippo F Fernández-Rodríguez Carmen C Dominici Paola P Martínez-Cruz Luis Alfonso LA Astegno Alessandra A
International journal of molecular sciences 20220725 15
Cystathionine beta-synthase (CBS) is a key regulator of homocysteine metabolism. Although eukaryotic CBS have a similar domain architecture with a catalytic core and a C-terminal Bateman module, their regulation varies widely across phyla. In human CBS (HsCBS), the C-terminus has an autoinhibitory effect by acting as a cap that avoids the entry of substrates into the catalytic site. The binding of the allosteric modulator AdoMet to this region alleviates this cap, allowing the protein to progres ...[more]