Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting.

ABSTRACT:

Background

The activation of the hypothalamic-pituitary-adrenal (HPA) axis is essential for metabolic adaptation in response to fasting. However, the neurocircuitry connecting changes in the peripheral energy stores to the activity of hypothalamic paraventricular corticotrophin-releasing factor (CRF^PVN) neurons, the master controller of the HPA axis activity, is not completely understood. Our main goal was to determine if hypothalamic arcuate nucleus (ARC) POMC and AgRP neurons can communicate fasting-induced changes in peripheral energy stores, associated to a fall in plasma leptin levels, to CRF^PVN neurons to modulate the HPA axis activity in mice.

Results

We observed increased plasma corticosterone levels associate with increased CRF^PVN mR

SUBMITTER: Fernandes ACA 

PROVIDER: S-EPMC9331576 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature