Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice.

ABSTRACT: Cellular senescence, one of the hallmarks of aging, refers to permanent cell cycle arrest and is accelerated during the aging process. Black ginseng (BG), prepared by a repeated steaming and drying process nine times from fresh ginseng (Panax ginseng C.A. Meyer), is garnering attention for herbal medicine due to its physiological benefits against reactive oxygen species (ROS), inflammation, and oncogenesis, which are common cues to induce aging. However, which key nodules in the cellular senescence process are regulated by BG supplementation has not been elucidated yet. In this study, we investigated the effects of BG on cellular senescence using in vitro and aged mouse models. BG-treated primary mouse embryonic fibroblasts (MEFs) in which senescence was triggered by ionizing radiat

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC9331701 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature