Synthesis of Celecoxib-Eutectic Mixture Particles via Supercritical CO₂ Process and Celecoxib Immediate Release Tablet Formulation by Quality by Design Approach.

ABSTRACT: Significant improvements in the wettability and dissolution rate of celecoxib (CEL), a poorly soluble selective cyclooxygenase-2 (COX-2) inhibitor, have been shown by Huyn et al., 2019 by combining the binary pharmaceutical compositions including CEL and one of the two co-formers, adipic acid (ADI) and saccharin (SAC), into eutectic mixtures (EM). Purpose: In this study, we developed a therapeutic eutectic system for CEL which is a promising approach for oral delivery to enhance bioavailability. CEL EM were synthesized by novel techniques including supercritical CO₂ techniques and new tablet formulations were purposed. Methods: CEL EM were synthesized by evaporation crystallization method, spray drying, supercritical fluid (SCF) techniques. The CEL EM particles wer

SUBMITTER: Hong SH 

PROVIDER: S-EPMC9331714 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature