Prognostic and predictive value of radiomic signature in stage I lung adenocarcinomas following complete lobectomy.

ABSTRACT:

Background

The overall survival (OS) of stage I operable lung cancer is relatively low, and not all patients can benefit from adjuvant chemotherapy. This study aimed to develop and validate a radiomic signature (RS) for prediction of OS and adjuvant chemotherapy candidates in stage I lung adenocarcinoma.

Methods

A total of 474 patients from 2 centers were divided into 1 training (n = 287), 1 internal validation (n = 122), and 1 external validation (n = 65) cohorts. We extracted 1218 radiomic features from preoperative CT images and constructed RS. We further investigated the prognostic value of the RS in survival analysis. Interaction between treatment and RS was assessed to evaluate its predictive value. Propensity score matching (PSM) was conducted.

Results

Overall,

SUBMITTER: Nie W 

PROVIDER: S-EPMC9331779 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature