CD146 Defines a Mesenchymal Stromal Cell Subpopulation with Enhanced Suppressive Properties.

ABSTRACT: Mesenchymal stromal cells (MSCs) are largely known for their immune-suppressive capacity, hence, their common use in the control of unwanted inflammation. However, novel concepts related to their biology, combined with the urgent need to identify MSC subpopulations with enhanced suppressive properties, drive the search for isolation protocols optimized for clinical applications. We show, in this study, that MSCs expressing high CD146 levels exhibit altered surface expression profiles of CD44 and secrete elevated levels of interleukin (IL)-6, amongst other factors. In addition, CD146^hi MSCs surpass the polyclonal parental populations in inhibiting alloreactive T cells in vitro, in both a soluble- and cell-contact-dependent manner. Despite the lack of CD146^hi MSC-mediat

SUBMITTER: Bikorimana JP 

PROVIDER: S-EPMC9331786 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature