RclS Sensor Kinase Modulates Virulence of Pseudomonas capeferrum.

ABSTRACT: Signal transduction systems are the key players of bacterial adaptation and survival. The orthodox two-component signal transduction systems perceive diverse environmental stimuli and their regulatory response leads to cellular changes. Although rarely described, the unorthodox three-component systems are also implemented in the regulation of major bacterial behavior such as the virulence of clinically relevant pathogen P. aeruginosa. Previously, we described a novel three-component system in P. capeferrum WCS358 (RclSAR) where the sensor kinase RclS stimulates the intI1 transcription in stationary growth phase. In this study, using rclS knock-out mutant, we identified RclSAR regulon in P. capeferrum WCS358. The RNA sequencing revealed that activity of Rc

SUBMITTER: Novovic K 

PROVIDER: S-EPMC9331949 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature