Identification of Critical Genes and Pathways for Influenza A Virus Infections via Bioinformatics Analysis.

ABSTRACT: Influenza A virus (IAV) requires the host cellular machinery for many aspects of its life cycle. Knowledge of these host cell requirements not only reveals molecular pathways exploited by the virus or triggered by the immune system but also provides further targets for antiviral drug development. To uncover critical pathways and potential targets of influenza infection, we assembled a large amount of data from 8 RNA sequencing studies of IAV infection for integrative network analysis. Weighted gene co-expression network analysis (WGCNA) was performed to investigate modules and genes correlated with the time course of infection and/or multiplicity of infection (MOI). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to explore the biolo

SUBMITTER: Chen G 

PROVIDER: S-EPMC9332270 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature