The Role of PIM Kinases in Pediatric Solid Tumors.

ABSTRACT: PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.

SUBMITTER: Julson JR 

PROVIDER: S-EPMC9332273 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature