The immunomodulatory potential of phage therapy to treat acne: a review on bacterial lysis and immunomodulation.

ABSTRACT:

Background

Characterized by an inflammatory pathogenesis, acne is the most common skin disorder worldwide. Altered sebum production, abnormal proliferation of keratinocytes, and microbiota dysbiosis represented by disbalance in Cutibacterium acnes population structure, have a synergic effect on inflammation of acne-compromised skin. Although the role of C. acnes as a single factor in acne development is still under debate, it is known that skin and skin-resident immune cells recognize this bacterium and produce inflammatory markers as a result. Control of the inflammatory response is frequently the target for acne treatment, using diverse chemical or physical agents including antibiotics. However, some of these treatments have side effects that compromise patient adhe

SUBMITTER: Farfan J 

PROVIDER: S-EPMC9332329 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature