Genome-Wide Association Analysis for Chronic Superficial Keratitis in the Australian Racing Greyhound.

ABSTRACT: Chronic superficial keratitis (CSK) is a progressive inflammatory condition of the eye (cornea) that can cause discomfort and blindness. Differential disease risk across dog breeds strongly suggests that CSK has a genetic basis. In addition to genetic risk, the occurrence of CSK is exacerbated by exposure to ultraviolet light. Genome-wide association analysis considered 109 greyhounds, 70 with CSK and the remainder with normal phenotype at an age over four years. Three co-located variants on CFA18 near the 5' region of the Epidermal Growth Factor Receptor (EGFR) gene were associated with genome-wide significance after multiple-test correction (BICF2P579527, CFA18: 6,068,508, p_raw = 1.77 × 10^-7, p_genome = 0.017; BICF2P1310662, CFA18: 6,077,388, p

SUBMITTER: Karamatic S 

PROVIDER: S-EPMC9332392 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature