Synthesis, Antifungal Activity, Cytotoxicity and QSAR Study of Camphor Derivatives.

ABSTRACT: Control of fungal phytopathogens affecting crops and woodlands is an important goal in environmental management and the maintenance of food security. This work describes the synthesis of 37 camphor derivatives, of which 27 were new compounds. Their antifungal effects on six fungi were evaluated in vitro. Compounds 3a, 4a and 5k showed strong antifungal activity against Trametes versicolor, with EC₅₀ values of 0.43, 6.80 and 4.86 mg/L, respectively, which were better than that of tricyclazole (EC₅₀ 118.20 mg/L) and close to or better than that of carbendazim (EC₅₀ 1.20 mg/L). The most potent compound, 3a, exhibited broad-spectrum antifungal activity towards six fungi with EC₅₀ values within the range of 0.43-40.1

SUBMITTER: Duan X 

PROVIDER: S-EPMC9332567 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature