The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.

ABSTRACT:

Background

The incidence of endometrial cancer (EC) is still rising. Numerous risk factors including patient characteristics and molecular instability have been identified for EC. The presence of specific molecular markers allows specific diagnostic and prognostic approaches. Several single nucleotide polymorphisms (SNPs) have been identified to influence endometrial cancer risk. Metalloestrogens are metal ions which can mimic estrogen activity; however, their role in uterine pathologies remains unknown. This study aimed to investigate total blood trace elements levels and evaluate the distribution of selected genotypes in GSTP1 and SLC11A2 genes.

Methods

This retrospective case-control analysis was carried out in peripheral blood samples of 110 women with endometrial cancer

SUBMITTER: Michalczyk K 

PROVIDER: S-EPMC9332856 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature