The Protective Effect of the Soluble Egg Antigen of Schistosoma japonicum in A Mouse Skin Transplantation Model.

ABSTRACT:

Background

Organ transplantation is currently an effective method for treating organ failure. Long-term use of immunosuppressive drugs has huge side effects, which severely restricts the long-term survival of patients. Schistosoma can affect the host's immune system by synthesizing, secreting, or excreting a variety of immunomodulatory molecules, but its role in transplantation was not well defined. In order to explore whether Schistosoma-related products can suppress rejection and induce long-term survival of the transplant, we used soluble egg antigen (SEA) of Schistosoma japonicum in mouse skin transplantation models.

Materials and methods

Each mouse was intraperitoneally injected with 100 μg of SEA three times a week for four consecutive weeks before

SUBMITTER: Jiang J 

PROVIDER: S-EPMC9332893 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature