Neoadjuvant and Adjuvant Chemotherapy for Variant Histology Bladder Cancers: A Systematic Review and Meta-Analysis.

ABSTRACT:

Context

To improve the prognosis of variant histology (VH) bladder cancers, clinicians have used neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) on the basis of radical cystectomy (RC). Despite some new data, the evidence remains mixed on their efficacy.

Objective

To update the current evidence on the role of NAC and AC for VH bladder cancers.

Evidence acquisition

We searched for all studies investigating NAC or AC for bladder cancer patients with variant histology in PubMed, Embase, and the Cochrane Central Register of Controlled Trials up to December 2021. The primary end points were recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS).

Evidence synthesis

We identified 18 reports comprising a total of 10,192 p

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC9333064 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature