Diagnostic Performance of Sex-Specific Modified Metabolite Patterns in Urine for Screening of Prediabetes.

ABSTRACT:

Aims/hypothesis

Large-scale prediabetes screening is still a challenge since fasting blood glucose and HbA_1c as the long-standing, recommended analytes have only moderate diagnostic sensitivity, and the practicability of the oral glucose tolerance test for population-based strategies is limited. To tackle this issue and to identify reliable diagnostic patterns, we developed an innovative metabolomics-based strategy deviating from common concepts by employing urine instead of blood samples, searching for sex-specific biomarkers, and focusing on modified metabolites.

Methods

Non-targeted, modification group-assisted metabolomics by liquid chromatography-mass spectrometry (LC-MS) was applied to second morning urine samples of 340 individuals from a prediabetes cohort

SUBMITTER: Li Z 

PROVIDER: S-EPMC9333093 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature