P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.

ABSTRACT: Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral deposition and inflammation. One potential link is the P2X7 purinoceptor, a key trigger of inflammation, which is expressed on macrophages but also up-regulated in dystrophic muscle cells. To investigate the role of P2X7 in dystrophic calcification, we utilised the Dmd ^mdx-βgeo dystrophin-null mouse model of DMD crossed with a global P2X7 knockout (P2rx7 ^-/- ) or with our novel P2X7 knockin-knockout mouse (P2x7 ^KiKo ), which expresses P2X7 in macrophages but not muscle cells

SUBMITTER: Rumney RMH 

PROVIDER: S-EPMC9333129 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature