Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts.

ABSTRACT:

Background

Venous thromboembolism (VTE) diagnosis would greatly benefit from the identification of novel biomarkers to complement D-dimer, a marker limited by low specificity. Neutrophil extracellular traps (NETs) have been shown to promote thrombosis and could hypothetically be used for diagnosis of acute VTE.

Objectives

To assess the levels of specific markers of neutrophil activation and NETs and compare their diagnostic accuracy to D-dimer.

Methods

We measured plasma levels of neutrophil activation marker neutrophil elastase (NE), the NET marker nucleosomal citrullinated histone H3 (H3Cit-DNA) and cell-free DNA in patients (n = 294) with suspected VTE (pulmonary embolism and deep vein thrombosis) as well as healthy controls (n = 30). A total of 112 VTE positive an

SUBMITTER: Smith P 

PROVIDER: S-EPMC9333265 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature