Quantitative interpretation of Sedia LAg Assay test results after HIV diagnosis.

ABSTRACT:

Background

Testing for 'recent HIV infection' is common in surveillance, where only population-level estimates (of incidence) are reported. Typically, 'recent infection' is a category, obtained by applying a threshold on an underlying continuous biomarker from some laboratory assay(s). Interpreting the biomarker values obtained for individual subjects, as estimates of the date of infection, has obvious potential applications in the context of studies of early infection, and has also for some years attracted significant interest as an extra component of post-test counselling and treatment initiation. The applicable analyses have typically run aground on the complexity of the full biomarker growth model, which is in principle a non-linear mixed-effects model of unknown structure, the

SUBMITTER: Sempa JB 

PROVIDER: S-EPMC9333292 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature