Extended Anticoagulation After Pulmonary Embolism: A Multicenter Observational Cohort Analysis.

ABSTRACT: Background Pulmonary embolism (PE) has a long-term risk of adverse events, which can be prevented by extended anticoagulation. We compared clinical characteristics and outcomes between patients treated with 2-year extended anticoagulation and those who were not, in a population who had completed an initial phase of 3 to 6 months of anticoagulant therapy after acute PE. Methods and Results Observational cohort analysis of patients with PE who survived an initial phase of 3 to 6 months anticoagulation. Primary efficacy outcome was all-cause death or recurrent venous thromboembolism. Primary safety outcome was major bleeding. In total, 858 (71.5%) patients were treated with and 341 (28.5%) were treated without extended anticoagulant therapy during the active study period. Age <65 years, inter

SUBMITTER: Chopard R 

PROVIDER: S-EPMC9333394 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature