Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke.

ABSTRACT: Understanding circuit-level manipulations that affect the brain's capacity for plasticity will inform the design of targeted interventions that enhance recovery after stroke. Following stroke, increased contralesional activity (e.g. use of the unaffected limb) can negatively influence recovery, but it is unknown which specific neural connections exert this influence, and to what extent increased contralesional activity affects systems- and molecular-level biomarkers of recovery. Here, we combine optogenetic photostimulation with optical intrinsic signal imaging to examine how contralesional excitatory activity affects cortical remodeling after stroke in mice. Following photothrombosis of left primary somatosensory forepaw (S1FP) cortex, mice either recovered spontaneously or received chron

SUBMITTER: Bice AR 

PROVIDER: S-EPMC9333991 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature