Radiomic Signatures for Predicting EGFR Mutation Status in Lung Cancer Brain Metastases.

ABSTRACT:

Background

Lung cancer is the most common primary tumor metastasizing to the brain. A significant proportion of lung cancer patients show epidermal growth factor receptor (EGFR) mutation status discordance between the primary cancer and the corresponding brain metastases, which can affect prognosis and therapeutic decision-making. However, it is not always feasible to obtain brain metastases samples. The aim of this study was to establish a radiomic model to predict the EGFR mutation status of lung cancer brain metastases.

Methods

Data from 162 patients with resected brain metastases originating from lung cancer (70 with mutant EGFR, 92 with wild-type EGFR) were retrospectively analyzed. Radiomic features were extracted using preoperative brain ma

SUBMITTER: Zheng L 

PROVIDER: S-EPMC9334014 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature