Differences in Muscle Quantity and Quality by HIV Serostatus and Sex.

ABSTRACT:

Objective

People with HIV (PWH) experience greater declines in both muscle function and muscle mass with aging. Whether changes in muscle quality and quantity with aging differ between men and women with HIV and the implications on muscle function are not established.

Design

In coordinated substudies of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study, participants completed physical function and falls assessments; total trunk/thigh density, inversely related to fatty infiltration, and area were quantified from computed tomography (CT) scans.

Methods

Generalized linear models were used to explore variables affecting density/area, and associations between area/density and physical function and falls.

Results

CT scans were available on 387 men

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC9334131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature